CDK8 anticorps (AA 245-272)

N° du produit ABIN5532872

Cet anticorps Lapin Polyclonal détecte spécifiquement CDK8 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour CDK8 anticorps (AA 245-272) (ABIN5532872)

Antigène: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDK8 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CDK8 anticorps

Épitope: AA 245-272

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This Mouse Cdk8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-272 amino acids from the Central region of mouse Cdk8.

Isotype: Ig Fraction

Information d'application

Indications d'application: For WB starting dilution is: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Détails sur CDK8

Antigène: CDK8 (Cyclin-Dependent Kinase 8 (CDK8))

Autre désignation: Cdk8

Sujet: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation (By similarity).

Poids moléculaire: 53 kDa

ID gène: 264064

UniProt: Q8R3L8

Pathways: Cycle Cellulaire, Regulation of Lipid Metabolism by PPARalpha